A Validated Stability Indicating High Performance Reverse Phase Liquid Chromatographic Method for the Determination of Cilostazol in Bulk Drug Substance

ABSTRACT

A simple, rapid and accurate reverse phase high-performance liquid chromatographic (RP-HPLC) method was developed for the quantitative determination of cilostazol. The developed method is also applicable for the related substance determination in bulk drugs. The chromatographic separation was achieved on reversed-phase C-18 column. Eluents were monitored on photo-diode array detector at a wavelength of 210 nm using a mixture (50:50) of water and acetonitrile. Solution concentrations were quantified by external calibration. In the developed HPLC method, resolution between cilostazol and its potential impurities, namely Imp-A, Imp-B, and Imp-C were found greater than two. The drug was subjected to stress condition of hydrolysis, oxidation, photolysis and thermal degradation. Considerable degradation was found to occur in alkaline medium stress condition. The developed RP-HPLC method was validated with respect to linearity, accuracy, precision, stability of analytical solutions, and robustness.     

热处理生产信息智能化解决方案

根据热处理工艺的生产特点,按照数据存储的要求将热处理工艺数据化。同时利用数据库存取访问技术对生产过程记录和过程参数进行实时跟踪记录和存储,并利用互联网技术实现生产全过程的可视化和移动终端的浏览访问,从而实现热处理生产过程的信息化。自动采集、存储和访问,为热处理的智能化生产提供了良好的解决方案。     

基于动态策略的移动警务终端安全管控系统的设计与实现

对移动警务安全接入平台中的终端设备的安全防护问题进行了研究,提出并研制了一种基于动态策略的移动警务终端安全管控系统,整个系统由客户端、前置服务端和内网服务端组成,前置服务端和内网服务端分别部署在前置区和公安内网,客户端部署在移动终端设备上,确保在移动接入区和公安内网区有效进行物理隔离的前提下,将系统制定的各种安全策略规则下发到客户端执行,规范用户对移动终端的本地软硬件资源和网络资源的使用,实现安全威胁检测、防护及预警,对移动终端用户的违规访问、操作行为进行全面监测和上报,实现终端设备安全和行为的统一管理.     

ProVoc: An app to train vocabulary depth in order to foster children's reading comprehension

Many studies have demonstrated the crucial role of vocabulary in predicting reading performance in general. More recent work has indicated that one particular facet of vocabulary (its depth) is more closely related to language comprehension, especially inferential comprehension. On this basis, we developed a training application to specifically improve vocabulary depth. The objective of this study was to test the effectiveness of a mobile application designed to improve vocabulary depth. The effectiveness of this training was examined on 3rd and 4th grade children's vocabulary (breadth and depth), decoding and comprehension performances. A randomized waiting-list control paradigm was used in which an experimental group first received the intervention during the first 4 weeks (between pretest and post-test1), thereafter, a waiting control group received the training for the next 4 weeks (between postest1 and posttest2). Results showed that the developed application led to significant improvements in terms of vocabulary depth performance, as well as a significant transfer effect to reading comprehension. However, we did not observe such a beneficial effect on either vocabulary breadth or written word identification. These results are discussed in terms of the links between vocabulary depth and comprehension, and the opportunities the app presents for remedying language comprehension deficits in children.     

基于物联网终端管理云平台的大数据运维

近年来,随着快递物流、新零售、医疗卫生等行业信息化的快速发展,智能移动终端解决方案迅速普及,基于Android操作系统的智能移动终端被广泛应用。企业IT架构不断扩展,同时网络情况变得更加复杂,分支机构众多的大型企业这种情况能加明显。为了保证终端用户的良好体验以及数据的准确性和实效性,终端运维工作愈加困难。在运维过程中虽然已经运用自动化工具,但是管理系统时时采集、加工以及分析数据对运维工作是个巨大挑战。     

A study on the relationships among hand muscles and form factors of large-screen curved mobile devices

The aim of this study is to determine the effect of form factors (curvature rate, depth) of mobile devices on hand comfort when using large-screen curved mobile devices. To that end, four muscles (APB, APL, FDI, EDC) were selected and mockups for experiment were developed with four curvature rate levels (flat/100/200/300R) and five depth levels (3/5/7/9/11 mm). User experiment was conducted using three interactions (tapping, dragging, and texting) that usually take place on smartphones. EMG signal of each participant was measured. Combination of curvature and depth could maximize the physical comfort of hands and fingers through the experiment so that the interaction effect between form factors and tasks could be identified. Our results revealed that only APL and FDI had statistically significant muscle activity amounts across the curvature rates. With respect to effect of depth, all four muscles showed statistically significant difference in muscle activity. Moreover, results from the interaction effect among task levels of two tasks (target location of tapping and direction of dragging) and two form factors showed no interaction effect in either tapping or texting. The results of this study could be used to determine the optimal range for form factors of curved screen mobile devices in terms of physical comfort of the hand while using large-screen devices.     

A tree-based address configuration for a MANET

This paper proposes an address configuration scheme for a MANET. In this paper, the tree-based architecture and the algorithm of constructing a MANET are presented. In this architecture, a proxy node can assign a unique address for neighbor new nodes, so the address configuration task is distributed around all proxy nodes. The transmission of control packets is controlled within one-hop scope, so the cost is reduced and the delay is shortened. Through this architecture, the address resources released by failed nodes can be automatically reclaimed for reuse, so a proxy node has always the sufficient address space for assignment. In order to ensure the uniqueness of a node’s address, the paper also proposes the MANET merging and partitioning algorithms. Finally, this paper evaluates the performance metrics of both the proposed scheme and the existing schemes, and the results show that the proposed scheme reduces the address configuration cost and shortens the address configuration delay.     

节点度估计和静态博弈转发策略的Ad Hoc网络路由协议

针对Ad Hoc网络路由发现过程中广播路由请求分组导致的广播风暴问题，提出了一种基于节点度估计和静态博弈转发策略的Ad Hoc网络路由协议NGRP.NGRP考虑边界影响，采用分段函数的思想将网络场景分为中心、边和角区域，分别估算网络中节点在不同区域的节点度，避免了周期性广播Hello消息获取节点度导致的开销；NGRP路由请求分组的转发采用静态博弈转发策略，利用节点度估算参与转发路由请求分组的节点数量，将转发和不转发作为策略集合，设计效益函数，通过纳什均衡获得节点转发路由请求分组的转发概率，从而减少了路由请求分组广播过程中产生的大量的冗余、竞争和冲突，提高了路由发现过程中路由请求分组的广播效率.运用NS-2对协议的性能进行大量的仿真，结果表明：NGRP的分组投递率、路由开销、MAC层路由开销和吞吐率这4项指标明显优于AODV+FDG，AODV with Hello和AODV without Hello协议.     

Development of mobile miniature natural gas liquefiers

With increasing consumption of natural gas (NG), small NG reservoirs, such as coalbed methane and oil field associated gas, have recently drawn significant attention. Owing to their special characteristics (e.g., scattered distribution and small output), small-scale NG liquefiers are highly required. Similarly, the mixed refrigerant cycle (MRC) is suitable for small-scale liquefaction systems due to its moderate complexity and power consumption. In consideration of the above, this paper reviews the development of mobile miniature NG liquefiers in Technical Institute of Physics and Chemistry (TIPC), China. To effectively liquefy the scattered NG and overcome the drawbacks of existing technologies, three main improvements, i.e., low-pressure MRC process driven by oil-lubricated screw compressor, compact cold box with the new designed heat exchangers, and standardized equipment manufacturing and integrated process technology have been made. The development pattern of “rapid cluster application and flexible liquefaction center” has been eventually proposed. The small-scale NG liquefier developed by TIPC has reached a minimum liquefaction power consumption of about 0.35 kW·h/Nm³. It is suitable to exploit small remote gas reserves which can also be used in boil-off gas reliquefaction and distributed peak-shaving of pipe networks.